Error: Could not load file or assembly 'file:///C:\Users\xxxxx\AppData\Local\Temp\Temporary ASP.NET Files\website6\729e7299\82e765ff\App_Web_8ysocxbb.dll' or one of its dependencies. The system cannot find the file specified.

Hi,
I am getting the following error when traying to run a web application project on VS2008, 3.5 sp1.
Error    1    Could not load file or assembly 'file:///C:\Users\xxxxx\AppData\Local\Temp\Temporary ASP.NET Files\website6\729e7299\82e765ff\App_Web_8ysocxbb.dll' or one of its dependencies. The system cannot find the file specified.  


In solution Explorer,  right click on Default.aspx ->  View in Browser, the following error appears on the web page in browser.


The resource cannot be found.
Server Error in '/WebSite6' Application. The resource cannot be found. Description: HTTP 404. The resource you are looking for (or one of its depend ...