System.UnauthorizedAccessException: Access to the path

So I am getting the following error and I need some help please

System.UnauthorizedAccessException: Access to the path 'C:\Inetpub\wwwstage\nexavar.egofactory.com\Resources\Nexavar_PI.pdf' is denied. at System.IO.__Error.WinIOError(Int32 errorCode, String maybeFullPath) at System.IO.FileStream.Init(String path, FileMode mode, FileAccess access, Int32 rights, Boolean useRights, FileShare share, Int32 bufferSize, FileOptions options, SECURITY_ATTRIBUTES secAttrs, String msgPath, Boolean bFromProxy) at System.IO.FileStream..ctor(String path, FileMode mode, FileAccess access, FileShare share) at System.IO.File.Open(String path, FileMode mode) at Nexavar.FileDownload_Default.OpenDocument() in C:\Users\JClark\My Documents\Visual Studio 2008\Projects\nexavar.egofactory.com\nexavar.egofactory.com\FileDownload\Default.aspx.vb:line 94 at Nexavar.FileDownload_Default.Page_Load(Object sender, EventArgs e) in C:\Users\JClark\My Documents\ ...