Web Service Failed: 404 - popupcontrolextender onmouseover/out

 here is my ascx code:
 <div style="width:95%; font-family:Tahoma; font-size:smaller">                  
<asp:Panel ID="Panel1" runat="server">
<!--<div style="overflow-y: scroll; height: 200px">-->
<asp:GridView ID="gvMemberInsurance" runat="server"   DataKeyNames="GUID"
             AutoGenerateColumns="False" BackColor="LightGoldenrodYellow"
            BorderColor="Tan" BorderWidth="1px" CellPadding="2" ForeColor="Black" GridLines="None"
           AllowPaging="True" AllowSorting="True" O ...