Interesting metter is the page_load event is not fired after thie page loaded once.

Hello all,
My aspx page is not showing latest data after reopen the page.. but after save data it shows latest information.
If I close the project and rerun the project then it shows latest data.
Interesting metter is the page_load event is not fired after thie page loaded once.
If I delete temporary internet files from tools-->internet option then the page reloaded. 
 
do u have any ideas what is going on at my page?
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